Incidence of IgA antibodies specific to benzo[a]pyrene and steroid hormones in women with colorectal cancer and breast cancer

Formation of DNA adducts chemical carcinogens is a trigger for carcinogenesis. Adducts benzo[a]pyrene metabolites and estradiol with have been found in normal tumor cells healthy women patients breast colorectal cancer. These low-weight compounds macromolecular complexes induce the synthesis specific antibodies. Previously, presence antibodies against (IgA-Bp), (IgA-Es) progesterone (IgA-Pg) was revealed cancer patients. The aim this study to identify putative features IgA-Bp, IgA-Es, IgA-Pg formation postmenopausal cancer, comparison Using noncompetitive enzyme-linked immunosorbent assay, content these studied blood serum (n = 401), 219) 1469) using conjugates Bp, Es, Pg bovine albumin as adsorbed antigens. When compared people, exhibited higher incidence IgA-Bp 3 (75% vs 37%, p 0.0001, OR 5.0), well more common levels individual antibody ratios: IgA-Bp/IgA-Es 1 (82% 41%, 6.5); IgA-Bp/IgA-Pg 1.5 (77% 20%, 13.4); IgA-Es/IgA-Pg (89% 48%, 8.7). In patients, high values ( 3) were (45% 0.004, 1.4), increased ratio (57% 1.9), 1.1 (71% 36%, 4.4) 3.5). we 45%, 0.0001), IgA-Es (53% 39%, 0, 0001), 2 (52% 44%, 0.025), IgA-Bp/IgA- Es 57%, 50.8 ); 49%, 0.0001); (85% 71%, 0.0001). apparently reflect DNA-Bp at large scale target due direct exposure colon epithelium Bp from food. Immunoassay proposed assessing risk women. ratios IgA Bp/IgA-Pg represent most informative marker